Interplay of Potassium Channels in Modulating the Action Potential of the Human Left Ventricle
Title:
Interplay of Potassium Channels in Modulating the Action Potential of the Human Left Ventricle
Authors:
Chong Wang TH ; Peter Beyerlein TH ; Heike Pospisil TH ; Antje Krause TH ; Werner Dubitzky ; Chris Nugent
Abstract:
The interplay of potassium ion channels in modulating
the action potential (AP) of the human left ventricle has
not been well elucidated due to the precise nature of some
underlying ionic components that are not fully character-
ized. In the current study, we have developed an allosteric
conformation model for rapid delayed rectifier (IKr) and
incorporated this into the ten Tusscher’s model for hu-
man ventricular myocytes. The transmural densities of IKr,
the slow delayed rectifier (IKs) and the transient outward
channel (Ito) were refined based on the variable expres-
sion of the underlying protein subunits. Our results demon-
strated that the modified model was able to reproduce an
AP duration (APD) of 313 ms in Epi, 349 ms in M and
300 ms in Endo at 1 Hz pacing. A frequency change from
1 Hz to 0.5 Hz resulted in an APD difference of 20 ms for
Epi, 32 ms for M and 20 ms for Endo. Ito effected the early
phase of AP, however, had no significant influence on APD.
An increase of IKr progressively suppressed IKs in Epi and
Endo, however, caused a paradoxical change of IKs in M
cells. In summary, our results have suggested a coincident
decrease of IKs with excessive decrease of IKr in M cells
would be a substrate of their high susceptibility to APD
prolongation.
Year:
2010
Publication type:
Journal article
Journal:
Computing in cardiology
ISSN:
0276−6574
Volume:
37
Pages:
653-656
Language:
English
Document status:
Open access
PubListerURL:
https://publister.bib.th-wildau.de/publister/public/publication/1630
Wang, C., Beyerlein, P., Pospisil, H., Krause, A., Dubitzky, W., & Nugent, C. (2010). Interplay of Potassium Channels in Modulating the Action Potential of the Human Left Ventricle Computing in cardiology. 37, 653-656.
@article{1630,
author = {Wang, Chong and Beyerlein, Peter and Pospisil, Heike and Krause, Antje and Dubitzky, Werner and Nugent, Chris},
title = {Interplay of Potassium Channels in Modulating the Action Potential of the Human Left Ventricle},
journal = {Computing in cardiology},
year = {2010},
volume = {37},
pages = {653-656},
url = {http://www.cinc.org/archives/2010/pdf/0653.pdf},
}