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A new triple system DNA-Nanosilver-Berberine for cancer therapy

Title:
A new triple system DNA-Nanosilver-Berberine for cancer therapy
Abstract:
The isoquinoline quaternary alkaloid Berberine possesses a variety of pharmacological properties that suggests its promising application for an anticancer delivery system design utilizing its ability to intercalate DNA. In the current work, we have investigated the effects of Berberine on the human T cell leukemia cell line in vitro. Fluorescent microscopy of leukemic cells revealed Berberine nuclear localization. The results showed that Berberine inhibited leukemic cell growth in a time- and dose-dependent manner, that was associated with reactive oxygen species production intensification and caspase 3/7 activity increase with followed apoptosis induction. Berberine was used as a toxic and phototoxic agent for triple system synthesis along with DNA as a carrier and nanosilver as a plasmonic accelerator of Berberine electronic transitions and high energy emission absorbent centers. The proposed method allows to obtain the complex of DNA with Berberine molecules and silver nanoparticles. The optical properties of free components as well as their various combinations, including the final triple system DNA-Nanosilver-Berberine, were investigated. Obtained results support the possibility to use the triple system DNA-Nanosilver-Berberine as an alternative therapeutic agent for cancer treatment.
Year:
2019
Publication type:
Journal article
Journal:
Applied Nanoscience
ISSN:
2190-5517
Number:
5
Volume:
9
Pages:
945–956
Language:
English
Document status:
Open access
PubListerURL:
https://publister.bib.th-wildau.de/publister/public/publication/2477
Keywords:
Berberine, Apoptosis, Nanosilver, DNA delivery system
Grebinyk, A., Yashchuk, V., Bashmakova, N., Gryn, D., Hagemann, T., Naumenko, A., et al. (2019). A new triple system DNA-Nanosilver-Berberine for cancer therapy Applied Nanoscience. 9 (5), 945–956.
@article{2477,
    author           = {Grebinyk, Anna and Yashchuk, Valeriy and Bashmakova, Nataliya and Gryn, Dmytro and Hagemann, Tobias and Naumenko, Antonina and Kutsevol, Nataliya and Dandekar, Thomas and Frohme, Marcus},
    title            = {A new triple system DNA-Nanosilver-Berberine for cancer therapy},
    journal          = {Applied Nanoscience},
    year             = {2019},
    volume           = {9},
    number           = {5},
    pages            = {945–956},
    publisher        = {Springer Nature},
    doi              = {10.1007/s13204-018-0688-x},
    url              = {https://link.springer.com/article/10.1007%2Fs13204-018-0688-x},
}


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