Hinweis (Dez. 2019): PubLister wird demnächst abgelöst. Publikationen der Technischen Hochschule Wildau werden zukünftig in HISinOne nachgewiesen. In diesem Zusammenhang kann es momentan zu Überarbeitungen und zu temporären Veränderungen Ihrer persönlichen Publikationslisten kommen. Bei weiteren Fragen wenden Sie sich bitte an friederike.borchert [at] th-wildau [dot] de.

In vitro and in vivo toxicity of pristine C60 fullerene aqueous colloid solution

Title:
In vitro and in vivo toxicity of pristine C60 fullerene aqueous colloid solution
Abstract:
Toxicity of the C60 fullerene aqueous colloid solution in vitro and in vivo experiments was studied. C60 fullerene in the concentration range of 3.6–144 µg/mL demonstrated low toxicity against human embryonic kidney (HEK293) cells with 383.4 μg/mL IC50 value. The acute toxicity of C60 fullerene in a dose progression (75, 150, 300, 600, 1200 and 1800 mg/kg) was investigated at 14th day after single intraperitoneal (i.p.) administration into mice. No toxic effect of С60 fullerene in the dose range of 75–150 mg/kg was observed; the calculated LD50 value was 721 mg/kg. The toxic effect of C60 fullerene was observed at a concentration of 300 mg/kg and higher, it was accompanied with mice behavior disturbance, hematotoxicity and pathomorphological changes in spleen, hepatic and kidney tissues. In mice treated with 600 mg/kg of C60 fullerene indices of inflammatory process were detected, whereas at 1200 mg/kg dose leukopoies and thrombocytopoies were found to be suppressed. Thus, C60 fullerene aqueous colloid solution in a dose range of 75–150 mg/kg is nontoxic and could be used for biomedical purposes.
Year:
2019
Publication type:
Journal article
Journal:
Fullerenes, Nanotubes and Carbon Nanostructures
ISSN:
1532-2343
Number:
9
Volume:
27
Pages:
715-728
Language:
English
Document status:
Published
PubListerURL:
https://publister.bib.th-wildau.de/publister/public/publication/2742
Keywords:
C60 fullerene, DLS and AFM analysis, fluorescent microscopy, IC50 and LD50 values, hematological and histological analysis
Prylutska, S., Grebinyk, A., Lynchak, O., Byelinska, I., Cherepanov, V., Tauscher, E., et al. (2019). In vitro and in vivo toxicity of pristine C60 fullerene aqueous colloid solution Fullerenes, Nanotubes and Carbon Nanostructures. 27 (9), 715-728.
@article{2742,
    author           = {Prylutska, Svitlana and Grebinyk, Anna and Lynchak, Oksana V. and Byelinska, Iryna V. and Cherepanov, Vsevolod V. and Tauscher, Eric and Matyshevska, Olga and Prylutskyy, Yu. and Rybalchenko, Volodymyr K. and Ritter, Uwe and Frohme, Marcus},
    title            = {In vitro and in vivo toxicity of pristine C60 fullerene aqueous colloid solution},
    journal          = {Fullerenes, Nanotubes and Carbon Nanostructures},
    year             = {2019},
    volume           = {27},
    number           = {9},
    pages            = {715-728},
    publisher        = {Taylor & Francis},
    doi              = {10.1080/1536383X.2019.1634055},
}


Search this title in Google Scholar