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Bioinformatics identifies tardigrade molecular adaptations including the DNA-j family and first steps towards dynamical modelling

Title:
Bioinformatics identifies tardigrade molecular adaptations including the DNA-j family and first steps towards dynamical modelling
Abstract:
Abstract Tardigrades are an independent animal phylum with remarkable adaptation against cold, heat, radiation and vacuum, which they outlast in a dormant stage (tun). Growing data resources and new large-scale data (e.g. from large EST sequencing projects) allows to investigate tardigrade-specific adaptations. Bioinformatical analysis and methods follow the flow of genetic information from DNA to proteins, from sequences to protein clusters, from pathways and dynamics of adaptations. These methods include the usage of internal transcribed spacer 2 as a new phylogenetic marker. Next we present recent examples of bioinformatical analysis on tardigrades for these steps. This includes specific RNA stability motifs. Clustering of protein families reveals tardigrade-specific protein families and pathway analysis allows insights into mechanisms of oxidative stress tolerance, protein repair, protein turnover, DNA protection and stress-pathways. We focus in more detail on the diversity of DNA-j-like proteins that enhances the adaptation potential of Milnesium tardigradum. Finally, a sketch of adaptation dynamics in tardigrades is presented including techniques for dynamical modelling; yet, quantitative modelling requires far more data and detail.
Year:
2011
Publication type:
Journal article
Journal:
Journal of Zoological Systematics and Evolutionary Research
ISSN:
0947-5745
Number:
Supplement s1
Volume:
49
Pages:
120-126
Language:
English
Document status:
Published
PubListerURL:
https://publister.bib.th-wildau.de/publister/public/publication/453
Keywords:
Clusters of orthologous groups; evolution; metabolism; genome analysis
Förster, F., Beisser, D., Frohme, M., Schill, R., & Dandekar, T. (2011). Bioinformatics identifies tardigrade molecular adaptations including the DNA-j family and first steps towards dynamical modelling Journal of Zoological Systematics and Evolutionary Research. 49 (Supplement s1), 120-126.
@article{453,
    author           = {Förster, Frank and Beisser, Daniela and Frohme, Marcus and Schill, Ralph O. and Dandekar, Thomas},
    title            = {Bioinformatics identifies tardigrade molecular adaptations including the DNA-j family and first steps towards dynamical modelling},
    journal          = {Journal of Zoological Systematics and Evolutionary Research},
    year             = {2011},
    volume           = {49},
    number           = {Supplement s1},
    pages            = {120-126},
    doi              = {10.1111/j.1439-0469.2010.00609.x },
}


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