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Comparative proteome analysis of Milnesium tardigradum in early embryonic state versus adults in active and anhydrobiotic state

Title:
Comparative proteome analysis of Milnesium tardigradum in early embryonic state versus adults in active and anhydrobiotic state
Abstract:
Tardigrades have fascinated researchers for more than 300 years because of their extraordinary capability to undergo cryptobiosis and survive extreme environmental conditions. However, the survival mechanisms of tardigrades are still poorly understood mainly due to the absence of detailed knowledge about the proteome and genome of these organisms. Our study was intended to provide a basis for the functional characterization of expressed proteins in different states of tardigrades. High-throughput, high-accuracy proteomics in combination with a newly developed tardigrade specific protein database resulted in the identification of more than 3000 proteins in three different states: early embryonic state and adult animals in active and anhydrobiotic state. This comprehensive proteome resource includes protein families such as chaperones, antioxidants, ribosomal proteins, cytoskeletal proteins, transporters, protein channels, nutrient reservoirs, and developmental proteins. A comparative analysis of protein families in the different states was performed by calculating the exponentially modified protein abundance index which classifies proteins in major and minor components. This is the first step to analyzing the proteins involved in early embryonic development, and furthermore proteins which might play an important role in the transition into the anhydrobiotic state.
Year:
2009
Publication type:
Journal article
Journal:
PLoS ONE
ISSN:
1932-6203
Number:
9
Volume:
7
Pages:
1-25
Language:
English
Document status:
Open access
PubListerURL:
https://publister.bib.th-wildau.de/publister/public/publication/51
Grohme, M., Frohme, M., Schokraie, E., Warnken, U., Hotz-Wagenblatt, A., Hengherr, S., et al. (2009). Comparative proteome analysis of Milnesium tardigradum in early embryonic state versus adults in active and anhydrobiotic state PLoS ONE. 7 (9), 1-25.
@article{51,
    author           = {Grohme, Markus Alexander and Frohme, Marcus and Schokraie, Elham and Warnken, Uwe and Hotz-Wagenblatt, Agnes and Hengherr, Steffen and Förster, Frank and Schill, Ralph O. and Dandekar, Thomas and Schnölzer, Martina},
    title            = {Comparative proteome analysis of Milnesium tardigradum in early embryonic state versus adults in active and anhydrobiotic state},
    journal          = {PLoS ONE},
    year             = {2009},
    volume           = {7},
    number           = {9},
    pages            = {1-25},
    doi              = {10.1371/journal.pone.0045682},
    url              = {http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045682},
}


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