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β-Carbolines: Occurrence, Biosynthesis, and Biodegradation

Title:
β-Carbolines: Occurrence, Biosynthesis, and Biodegradation
Subtitle:
New Vistas In Parkinson's Disease Therapy
Abstract:
Studies clearly demonstrated biosynthesis of β-carbolines (βCs) in animals and humans. Precursor compounds include serotonin (syn. 5-hydroxytryptamine), tryptamine, and tryptophan with either acetaldehyde or pyruvate as cosubstrates. βCs are metabolized efficiently. Alcohol consumption and smoking affect their biosynthesis and biodegradation. Alcohol consumption increases the biosynthesis of harman (1-me-βC) which induces voluntary alcohol intake possibly by increasing the activity of dopamine neurons of the mesolimbic system (see Chap. 10). On the other hand, smoking induces the biodegradation of βCs. Norharman-2-N-oxide, a metabolite of norharman (βC) in brain and liver protects norharman from methylation to neurotoxic βCs. Furthermore, βCs form complexes with acetic acid and other hydrogen donors which may prevent the N-methylation to the toxic quaternary cations. Progesterone binding to CYP17 is completely blocked by norharman in contrast to harman which indicates inhibition of androgen biosynthesis. These findings point to multiple functions and interactions of βCs some of which will be presented in more detail in subsequent chapters.
Year:
2012
Publication type:
Book chapter/section
Book title:
Isoquinolines and beta-carbolines as neurotoxins and neuroprotectants
Publisher:
Springer Science+Business Media, LLC: Springer
ISBN:
978-1-4614-1541-1
Series:
Current topics in neurotoxicity
Pages:
105-113
Language:
English
Document status:
Published
PubListerURL:
https://publister.bib.th-wildau.de/publister/public/publication/886
Rommelspacher, H., Wernicke, C., & Lehmann, J. (2012). β-Carbolines: Occurrence, Biosynthesis, and Biodegradation In Isoquinolines and beta-carbolines as neurotoxins and neuroprotectants. (pp. 105-113). Springer Science+Business Media, LLC: Springer.
@inbook{886,
    author           = {Rommelspacher, Hans and Wernicke, Catrin and Lehmann, Jochen},
    title            = {β-Carbolines: Occurrence, Biosynthesis, and Biodegradation},
    year             = {2012},
    pages            = {105-113},
    publisher        = {Springer},
    series           = {Current topics in neurotoxicity},
    address          = {Springer Science+Business Media, LLC},
    isbn             = {978-1-4614-1541-1},
    booktitle        = {Isoquinolines and beta-carbolines as neurotoxins and neuroprotectants},
    doi              = {10.1007/978-1-4614-1542-8_6},
}


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